A biography for David Andrew Sinclairhasn’t been written yet.
“The mice that had the resveratrol in their diet were still obese, but they were seemingly or relatively immune to the effects of the obesity. So their arteries were clear, their liver was nice and thin. Their bones were stronger. They could run further.”
“It's been known since 1916 that cutting back calories is beneficial in every organism it's been tested on - from yeast to worms to mice to monkeys. I think it would be a surprise if we are an exception to that rule.”
“Resveratrol does not act primarily as an antioxidant. It is far more interesting and powerful than that. Resveratrol turns on our body's genetic defenses against diseases and aging itself.”
“Doctors will prescribe medicines for a particular disease but, as a side effect, those medications will work to prevent dozens of others.”
“Well, we can study aging in people, but of course those studies take decades. So what we try to do is we use simpler organisms to try and understand the basic mechanisms and so in my laboratory, for example, we use things like simple baker's yeast that we use to make bread.”
“As we get better at reversing aging it will be possible to take one medicine and within weeks feel and even look younger. Imagine going to a doctor to get a pill for diabetes, and this same medicine will prevent heart disease, Alzheimer's, cancer, and will give you more vitality too.”
“Unfortunately, because aging is so common and natural, we tend to think of it as destiny or something we should accept.”
“We've always known that our bodies are capable of healing themselves under the right conditions: Diet and exercise improve our health. But there are also ancient genetic survival pathways in every living thing.”
“Scientists don't like to be called salesmen.”
“We can change our lives for the better, and always have. We used to think pain during surgery and dying during childbirth were inevitable. We no longer accept that, and we shouldn't just accept aging.”
“I actually think it will be possible one day to be immortal.”
“We once thought of cancer as an incurable disease; then we started treating it.”
“I was criticized for saying that Pfizer doesn't know how to make a molecule right.”
“So aging is really just the way we deteriorate over time. Lifespan on the other hand is how long we live. We typically refer to that as longevity.”
“Only 20 percent of our longevity is genetically determined. The rest is what we do, how we live our lives and increasingly the molecules that we take. It's not the loss of our DNA that causes aging, it's the problems in reading the information, the epigenetic noise.”
“I tried calorie restriction and couldn't do it. It's really hard to be hungry all the time.”
“I believe in my work and advocate for my conclusions.”
“If I'm not hungry and I'm busy, I am quite happy to skip a meal. It's informal intermittent fasting. I feel strongly that this is one of the strongest areas of longevity research.”
“The way to make a worm live longer is probably quite different from making a human live longer.”
“Resveratrol had a decent benefit when the mice were obese and sedentary. The mice that were fed a lean diet and resveratrol lived significantly longer than other treated mice as well as those that had no healthy diet and no resveratrol. So resveratrol is not an excuse to be lazy or eat whatever you want.”