Bryan Johnson

“Before Europeans learned about zero, Descartes could not have come up with Cartesian geometry. All anyone had ever tried was to do better and better Euclidean geometry. We need more such insights.”

“We can architect and work towards building any world we imagine, for ourselves and future generations.”

“When we aren't well, society isn't well; and the technology we build mirrors that.”

“Fear engages a cortisol/hormonal/fight-or-flight-get-out-of-Dodge response that shuts down all but the essential functions.”

“I'm shocked that sleep hygiene is not a global priority, and even more irate that my three children are expected to maintain school schedules that hinder adolescent development and contribute to mental illness.”

“Most people assume death is inevitable. We're just basically trying to prolong the time we have before we die.”

“The founding fathers were great entrepreneurs. They shipped something akin to a software product: the first version of the 'ideological operating system' of the United States.”

“It's terrifically hard to change what we can't measure.”

“Ultimately, climate change, infectious diseases and famine could meet their match with applied and synthetic biology.”

“Some of us are frugal with our money, others are spendthrifts. The same is true with how people manage their health and aging.”

“Building a successful future depends upon our ability to come up with new and unexpected ideas in governance, technology, social structures, cultural values and norms, among dozens of other things. These are some reasons why as an investor, I only invest in futures I cannot predict.”

“We are accustomed to first-principle thinking, where you assume the fewest number of things in a particular time frame. Zeroth-principle thinking is thinking from another dimension. It's another way of saying talent hits the target no one else can. Genius hits the target no one else can see.”

“Humans need simplifications in order to understand almost anything complex. That's one of our basic biases!”

“Most people start a business knowing what they're going to build, not trying to figure out what to do.”

“When humans can measure something, the first thing that always happens: an ecosystem of ideas and, eventually, industry springs up around it.”

“The future is unknown and dealing with unknowns is stressful. It is why imagining the future can be so scary for people and why anxieties become runaway fears.”

“I've structured my entire life around sleep. There's nothing I do in my life that influences my conscious existence more than my sleep. And so everything is built around that.”

“My objective with Blueprint is to demonstrate aging escape velocity, using the best science, trying to do all the appropriate interventions to neutralize my aging process.”

“The mind-bending fact that a common shrub is more advanced than the latest MacBook Pro is overlooked by almost everyone. We fail to see it for a simple reason: the coolest parts of a plant can't be seen. Not with the naked eye, at least.”

“Everything we are, everything we're building, everything we aspire to become, lives downstream from the brain.”