Archibald E. Garrod

“All the more recent work on alkaptonuria has... strengthened the belief that the homogentisic acid excreted is derived from tyrosine, but why alkaptonuric individuals pass the benzene ring of their tyrosine unbroken and how and where the peculiar chemical change from tyrosine to homogentisic acid is brought about, remain unsolved problems.”

“Nevertheless, scientific method is not the same as the scientific spirit. The scientific spirit does not rest content with applying that which is already known, but is a restless spirit, ever pressing forward towards the regions of the unknown, and endeavouring to lay under contribution for the special purpose in hand the knowledge acquired in all portions of the wide field of exact science. Lastly, it acts as a check, as well as a stimulus, sifting the value of the evidence, and rejecting that which is worthless, and restraining too eager flights of the imagination and too hasty conclusions.”